Proin for treating urinary incontinence in dogs

(redirects here from phenylpropanolamine)

Learn about Proin (phenylpropanolamine) for dogs, including the safe dosage, side effects, safety guidelines and more.

Phenylpropanolamine, the active ingredient in Proin (often stylized as “PROIN”), is a drug of the amphetamine and phenethylamine class effective in treating dogs with urinary incontinence (unintentional passing of urine). Proin is available by prescription only and so you will need to visit your vet first before administering the medication. You should be aware that in certain parts of the world including Arkansas, Iowa, Oregon and Louisiana Proin is considered a controlled substance.

Proin dosage for dogs

You should follow the specific instructions of your veterinarian when giving Proin to your pet. The dosage range for this medicine usually falls between 0.4 – 0.91 mg/lb body weight to be administered twice daily (12 hour intervals). The tablets are scored down the middle for easy dosing, with a liquid form (at a concentration of 25 mg/ml) available if required.

Is Proin safe for dogs?

As long as you follow the instructions of your vet carefully and administer the correct dosage, Proin is quite safe. However there are a few possible side effects you should anticipate when deciding whether to put your dog on Proin.

Safety precautions

  • Do not use this medication without first consulting a vet
  • Notify the vet of all existing medical conditions
  • Notify the vet of any other medication (including over-the-counter medicine and supplements) your dog is taking
  • Avoid administering Proin alongside or within 2 weeks of giving MAOI type substances to your pet
  • Never administer Proin alongside ephedrine or epinephrine

MAOI type substances may potentiate the effects of proin leading to overdose symptoms. Examples of MAOI substances includes medicines such as selegiline and PREVENTIC tick collars. Aside from this, Proin may cause adverse reactions in dogs with certain medical conditions, and may react with various other drugs. It’s important to provide plenty of water for your pet during treatment as he or she is likely to become excessively thirsty.

Uses of Proin for dogs

Proin is a medicine effective in treating canines suffering with:

  • Urinary incontinence

Side effects when giving Proin to your dog

Side effects of Proin when given to dogs may include hypertension, vomiting. diarrhea, weight loss, proteinuria (excess protein in urine), behavioral changes, excessive thirst, fatigue, insomnia and musculoskeletal disorders.

Be aware that some people believe Proin can lead to strokes, particularly in older more susceptible dogs. You should discuss this with your vet prior to use.

Complex medical information about this medicine
Generic information about phenylpropanolamine (Proin)