Selegiline for dogs with Cushing’s Disease or CDS

(redirects here from anipryl, l-deprenyl)

Read the following article for information about the use of selegiline for dogs, the correct dosage, side effects of the drug and more.

Selegiline (also known as Anipryl or L-Deprenyl) is a MAOI type substance which is often used by vets to treat dogs suffering from Cushing’s Disease and dementia (Cognitive Dysfunction Syndrome). Selegiline works by increasing levels of dopamine in the brain, and acts directly on the pituitary gland making it a less side effect prone than many other Cushing’s Disease treatments.

Selegiline dosage for dogs

The typical initial dose of selegiline for treatment of Cushing’s Disease is 0.45 mg/lb body weight to be administered once every morning. Usually your pet will be re-evaluated after 2 months, at which point the dosage may be increased depending on whether there is an improvement in the condition or not. For treatment of dementia, the dosage is typically 0.2 to 0.45 mg/lb administered once daily (24 hour intervals).

If your dog does not experience relief, remember that it may take up to a full month for improvements to become apparent. Never increase the dosage yourself without speaking to the vet.

Is selegiline safe for dogs?

Selegiline is one of the safer forms of treatment for Cushing’s Disease due to the fact that it acts directly on the pituitary gland. It is also FDA approved for use in animals and the first drug to be approved for the treatment of dementia in pets. As an MAOI it may interact with other substances, and as such, care must be practiced. It is also prescription only, which means you must not administer the drug without a prescription and approval to do so.

Safety precautions

  • Notify the vet of any other medication, substances or vitamins your pet is taking as selegiline may interact with substances such as clomipramine and meperidine
  • Notify the vet of any medical conditions your dog is afflicted with
  • Avoid administering SSRIs or tricyclic antidepressants for 14 full days after ceasing selegiline treatment
  • Notify the vet if your dog is pregnant or lactating
  • Do not administer to dogs with known sensitivity to MAOI substances

Because MAOIs potentiate the effects of many different medicines, particularly of the antidepressant class, it is important that you don’t administer any new substances to your pet throughout the course of treatment without first seeking veterinary approval. Never give selegiline to your dog if you do not have a prescription.

Uses of selegiline for dogs

Selegiline is usually given to dogs for the treatment of:

  • Dementia (CDS)
  • Cushing’s Disease

Selegiline (Anipryl, L-Deprenyl) is the first FDA approved drug for the treatment of canine Cognitice Dysfunction Syndrome.

Side effects of selegiline when given to dogs

Speak to your vet if your dog develops side effects such as nausea and/or diarrhea, fatigue, confusion, anxiety, insomnia and dizziness.

Discontinue use and seek emergency attention if your dog suffers serious side effects such as an allergic reaction, migraine, convulsions and odd uncontrollable/irregular movements.

Information about Anipryl (selegiline) for dogs
Lysodren for dogs, alernative Cushing’s Disease treatment